Physiological serum, Rhinovirus and Sars-COV2 When SARS-COV2/COVID19 emerged in early 2020, the lack of knowledge about the virus led to the appearance of numerous, often contradictory, and sometimes scientifically inappropriate guidelines. Taking stock of the knowledge gained over the last two years is important, especially regarding the application of saline, nasopharyngeal lavage, and nebulization practices. A great deal of work around the world has advanced knowledge to refine the understanding of saline use in rhinology. Download the full article or contact us Several relevant publications are summarized: A: Essentials in saline pharmacology for nasal or respiratory hygiene in times of Covid19 European Journal of Pharmacology 2021 – https://doi.org/10.1007/s00228-021-03102-3 B: Rapid initation of nasal saline irrigation: hospitalizations in Covid19 patients randomized to alkalinization or povidone-iodine compared to national dataset – https://doi.org/10.1101/2021.08.16.21262044 / Department of Emergency Medicine – Agusta University – Georgia USA / Preprint August 2021 – Not certified by peer review C: Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID 19 in front line health professionals. A randomized open label controlled trial in a general hospital in Mexico city. – Biomedical reports 16:11,2022 – DOI: 10.3892/br.2021.1494 D: Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease – Int Forum Allergy Rhinol. 2020;10,1325-1328 E: Nasal Irrigation in the Covid-19 Era – International Journal of clinical studies & medical case reports, September 2021 – DOI:10.46998/IJCMCR.2021.13.000314 Conclusion Since COVID 19 was a new virus, the fear of the unknown and the lack of knowledge about it led to most of the prevention actions being guided by the fear of spreading the virus. Hygiene measures that have been recognized for a long time, such as washing mucous membranes with saline solutions, had been discarded as a precautionary measure, primarily because of the fear of dissemination of the virus. This risk induced a benefit-risk ratio that did not appear favorable. […] 1 – Pfeifer M, Ewig S, Voshaar T et al (2020) Position paper for the state-of-the-art application of respiratory support in patients with COVID-19. Respiration 99:521–541. https://doi.org/10.1159/ 000509104 2 – Daviskas E, Anderson SD, Gonda I et al (1996) Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asth- matic and healthy subjects. Eur Respir J 9(4):725–732. https://doi. org/10.1183/09031936.96.09040725 3- . Fu Y, Tong J, Meng F et al (2018) Ciliostasis of airway epithelial cells facilitates Influenza A virus infection. Vet Res 49(1):65. https://doi.org/10.1186/s13567-018-0568-0 4- . Keojampa BK, Nguyen MH, Ryan MW (2004) Effects of buff- ered saline solution on nasal mucociliary clearance and nasal air- way patency. Otolaryngol Head Neck Surg 131(5):679–682. https://doi.org/10.1016/j.otohns.2004.05.026 5- Brown JR, Tang JW, Pankhurst L, Klein N, Gant V, Lai KM, et al. Influenza virus surviv al in aerosols and estimates of viable virus loss resulting from aerosolization and air-sampling. J Hosp Infect. 2015 Nov;91(3):278–81. 6 – Raboud J, Shigayeva A, McGeer A, Bontovics E, Chapman M, Gravel D, et al. Risk factors for SARS transmission from patients requir- ing intubation: a multicentre investigation in Toronto, Canada. PLoS One. 2010 May; 5(5):e10717. 7- Edwards DA, Man JC, Brand P, Katstra JP, Sommerer K, Stone HA, et al. Inhaling to mitigate exhaled bioaerosols. Proc Natl Acad Sci USA. 2004 Dec;101(50):17383–8. 8 – Rafael R. G. Machado,¶ Talita Glaser,¶ Danielle B. Araujo, Lyvia Lintzmaier Petiz, Danielle B. L. Oliveira, Giuliana S. Durigon, Alessandra L. Leal, Joaõ Renato R. Pinho, Luis C. S. Ferreira, Henning Ulrich,* Edison L. Durigon,* and Cristiane Rodrigues Guzzo* Inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 Replication by Hypertonic Saline Solution in Lung and Kidney Epithelial Cells ACS Pharmacol. Transl. Sci. 2021, 4, 1514−1527 ******************** ref 1 : https://pubmed.ncbi.nlm.nih.gov/32564028/ ref 2: https://www.researchgate.net/publication/14475382_Inhalation_of_hypertonic_saline_aerosol_enhances_mucociliary_clearance_in_asthmatic_and_healthy_subjects?enrichId=rgreq-6981d5e3f6b1a3a1647dc0529558768d-XXX&enrichSource=Y292ZXJQYWdlOzE0NDc1MzgyO0FTOjk4OTU1NjM5NjU2NDYxQDE0MDA2MDQyNzE2MTY%3D&el=1_x_3&_esc=publicationCoverPdf ref 3 : https://pubmed.ncbi.nlm.nih.gov/30021653/ ref 4 : https://pubmed.ncbi.nlm.nih.gov/15523448/ ref 5: https://pubmed.ncbi.nlm.nih.gov/26412395/ ref 6 : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010717 ref 7 : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC536048/ ref 8: https://pubmed.ncbi.nlm.nih.gov/34651104/